Investigator Initiated Trial (IIT)
Begin your initial submission by clicking here .


We are pleased that you are interested in conducting an Investigator Initiated Trial (IIT). Please read our General Information section prior to submitting your IIT request.

If instead of an IIT, you are looking to request a Sigma-Tau Educational Grant, click here and you will be redirected.

Sigma-Tau IIT Mission Statement  

Sigma-Tau Pharmaceuticals, Inc. is committed to advancing the delivery of quality healthcare by supporting Investigator Initiated Trials(IITs). This program is open to all academic and community-based physicians and researchers who are interested in conducting their own research in compliance with FDA regulations and all applicable laws.

Process for submission

All requests regarding VSL#3 should be sent to Sigma-Tau HealthScience USA, Inc. at

In keeping with Sigma-Tau Compliance Guidance, Sigma-Tau sales and marketing employees are prohibited from entering this website, and will not have access to this information.